I blogged about some problems we were having with an EMC NAS device and file locking with C#/.Net. It turns out the differences between the file systems were causing strange problems - it looked like phantom processes were holding locks on the files.
One of the guys on our team nailed this problem by using the NFS support in Windows Services for Unix 3.5. This tool is now free - there has been some talk that this is the last version of the product, it sounds like MS will be baking this capabilities into the new platforms moving forward.
Read: Fun with NAS devices and IIS - updated