I spotted this in a post from David Griswold (about the new V8 engine behind Google's Chrome browser):

I'm sure that these sorts of things can be worked around, but they do mean that V8 will never in its pure form quite reach the pinnacle of theoretical performance possible for a VM targeted specifically to Smalltalk etc. So it won't be as fast as Strongtalk, although it may get fairly close to VisualWorks performance.

That same VM powers ObjectStudio now - which is the only Vista Certified Smalltalk around. So - you know where to look for the best performance in Smalltalk.

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