I've been testing karmic for months, (which at times have been very painful - but if you join the beta ride, what else would it be), but in the last few weeks it looked like it was really coming together. 

The only big regression was the synaptics touchpad resetting the 'tap' setting after suspend resume cycle.

However, there was a kernel update last week which completely broke suspend (it never really sleeps the machine), and attempts to report it via the apport tool result in a invalid message about the kernel not being a ubuntu one.. (which someone has reported)

I'd really suggest anyone requiring resume/suspend to work, to hold of for a little while until they sort out the remaining issues.